SOX2 expression diminishes with ageing in several tissues in mice and humans

被引：25

作者：

Carrasco-Garcia, Estefania ^{[1
,8
]}

Moreno-Cugnon, Leire ^{[1
]}

Garcia, Idoia ^{[1
,7
,8
]}

Borras, Consuelo ^{[2
]}

Revuelta, Miren ^{[1
,9
]}

Izeta, Ander ^{[6
]}

Lopez-Lluch, Guillermo ^{[5
]}

de Pancorbo, Marian M. ^{[4
]}

Vergara, Itziar ^{[3
]}

Vina, Jose ^{[2
,8
]}

Matheu, Ander ^{[1
,7
,8
]}

机构：

[1] Biodonostia Hlth Res Inst, Cellular Oncol Grp, San Sebastian, Spain

[2] Univ Valencia, Fac Med, INCLIVA, FRESHAGE Grp, Valencia, Spain

[3] Biodonostia Hlth Res Inst, Hlth Res Chron Dis & Aging Grp, Primary Care Res Unit Gipuzkoa, Osakidetza,Kronikgune, San Sebastian, Spain

[4] Univ Basque Country, UPV EHU, Lascaray Res Ctr, BIOMICs Res Grp, Vitoria, Spain

[5] Pablo de Olavide Univ, Ctr Biomed Res Rare Dis CIBERER, Andalusian Ctr Dev Biol CABD, Dept Physiol Anat & Cell Biol, Seville, Spain

[6] Biodonostia Hlth Res Inst, Tissue Engn Lab, San Sebastian, Spain

[7] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

[8] CIBERfes, Madrid, Spain

[9] Charite, Med Ctr, Berlin, Germany

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2019年 / 177卷

关键词：

SOX2; Ageing; Biomarker; TRANSCRIPTION FACTORS; MOUSE DEVELOPMENT; STEM-CELLS; ROLES; BIOMARKERS; MUTATIONS; FAMILY; DIFFERENTIATION; P16(INK4A); GENERATION;

D O I：

10.1016/j.mad.2018.03.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal and adult tissues and its deregulated activity has been linked to chronic diseases associated with ageing. Nevertheless, the level of SOX2 expression in aged individuals at the tissue level has not previously been examined. In this work, we show that SOX2 expression decreases significantly in the brain with ageing, in both humans and rodents. The administration of resveratrol for 6 months in mice partly attenuated this reduction. We also identified an age-relateddecline in SOX2 mRNA and protein expression in several other organs, namely, the lung, heart, kidney, spleen and liver, Moreover, peripheral blood mononuclear cells (PBMCs) from elderly expressed lower levels of SOX2 than those from young individuals. Mechanistically, SOX2 expression inversely correlates with p16(Ink4a) levels. Together, these data show a widespread decrease in SOX2 with age, suggesting that the decline in SOX2 expression might be used as a biomarker of ageing.

引用

页码：30 / 36

页数：7

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