Neostatin-7 regulates bFGF-induced corneal lymphangiogenesis

被引：40

作者：

Kojima, Takashi ^{[1
]}

Azar, Dimitri T. ^{[1
]}

Chang, Jin-Hong ^{[1
]}

机构：

[1] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 17期

关键词：

collagen XVIII; neostatin-7; endostatin; lymphangiogenesis; bFGF;

D O I：

10.1016/j.febslet.2008.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neostatin- 7, with an anti- angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase- 7 on collagen XVIII. We previously reported that neostatin- 7 inhibited angiogenesis in vitro and in vivo. Here we demonstrate that neostatin- 7/ collagen XVIII may possess anti- lymphangiogenic activities by: ( 1) corneal micropellet implantation of neostatin7 reduced bFGF- induced corneal lymphangiogenesis; ( 2) neostatin- 7 bound to VEGF receptor- 3 in vitro; and ( 3) enhanced corneal lymphangiogenesis and VEGF- C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin- 7/ collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis- related disorders, such as lymphedema, transplantation rejection and cancers. Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.

引用

页码：2515 / 2520

页数：6

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