Curcumin loading and colon release of pectin gel beads: Effect of different de-esterification method

被引：57
作者：
Cai, Ran [1 ,2 ,3 ]
Pan, Siyu [1 ,2 ,3 ]
Li, Ruoxuan [1 ,2 ,3 ]
Xu, Xiaoyun [1 ,2 ,3 ]
Pan, Siyi [1 ,2 ,3 ]
Liu, Fengxia [1 ,2 ,3 ]
机构：
[1] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China
[2] Huazhong Agr Univ, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan, Hubei, Peoples R China
[3] Huazhong Agr Univ, Hubei Key Lab Fruit & Vegetable Proc & Qual Contr, Wuhan, Hubei, Peoples R China
来源：
FOOD CHEMISTRY | 2022年 / 389卷
基金：
中国国家自然科学基金;
关键词：
Pectin; Curcumin; Calcium gel beads; High hydrostatic pressure; Colon-targeted delivery; HIGH HYDROSTATIC-PRESSURE; DRUG-DELIVERY; CALCIUM; PH; ENCAPSULATION; STABILITY; CHITOSAN;
D O I：
10.1016/j.foodchem.2022.133130
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Low methoxyl citrus pectin (LMP) de-esterified from high hydrostatic pressure assisted enzymatic (HHP-pectin) and two other traditional methods was characterized, and curcumin-pectin calcium gel beads were prepared to study curcumin-loading and colon-targeted delivery abilities. It was found there was no significant difference among different LMP on amorphous structure, while significantly higher Rha/GalA ratio of HHP-pectin indicated higher rhamnogalacturonan I (RG-I) proportion and branching extent. Curcumin was well embedded in LMP beads with improved stability. HHP-pectin beads showed significantly higher hardness, chewiness and encapsulation efficiency, while lower swelling ratio. Moreover, in vitro simulated digestion showed gel beads can deliver curcumin to colon and inhibit premature release. HHP-pectin beads could release curcumin more quickly in colon, probably because of differences on texture properties, which may be depended on molecular structure. Thus, LMP especially HHP-pectin calcium gel as colon-targeted delivery system for curcumin may have potential application in function food and drug delivery.
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页数：11
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