KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma

被引：24
作者：
Abere, Bizunesh [1 ,2 ]
Schulz, Thomas F. [1 ,2 ]
机构：
[1] Hannover Med Sch, Inst Virol, Carl Neuberg Str 1, D-30625 Hannover, Germany
[2] German Ctr Infect Res, Hannover Braunschweig Site, Hannover, Germany
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 20卷
关键词：
MULTICENTRIC CASTLEMANS-DISEASE; PRIMARY EFFUSION LYMPHOMA; NF-KAPPA-B; LYMPHATIC ENDOTHELIAL-CELLS; YOUNG HOMOSEXUAL-MEN; ANGIOPOIETIN-LIKE; COUPLED RECEPTOR; GENE-EXPRESSION; SPINDLE CELLS; DNA-SEQUENCES;
D O I：
10.1016/j.coviro.2016.07.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Kaposi's sarcoma (KS) is an unusual neoplasm characterized by extensive neoangiogenesis, infiltrates of inflammatory cells and atypically differentiated spindle cells of endothelial origin. KS is caused by an oncogenic gamma-herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8). Several KSHV proteins can subvert multiple cellular angiogenic, mitogenic and inflammatory pathways. Here, we discuss the KSHV encoded membrane proteins vGPCR, K1 and K15, with a particular emphasis on their activation of cellular signaling pathways and their role in the development of specific features of KS.
引用
收藏
页码：11 / 19
页数：9
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