Facile, Flexible, Fast': Highly sensitive and Low-cost paper sensor for real time spike protein sensing with SERS

被引：5
|
作者：
Ramachandran, Krithikadevi [1 ]
Daoudi, Kais [1 ,2 ]
Columbus, Soumya [1 ]
Gaidi, Mounir [1 ,2 ,3 ]
Hammouche, Jannat [1 ,4 ,5 ]
Chidambaram, Siva [6 ]
机构：
[1] Univ Sharjah, Res Inst Sci & Engn, Ctr Adv Mat Res, Sharjah, U Arab Emirates
[2] Univ Sharjah, Dept Appl Phys & Astron, Sharjah, U Arab Emirates
[3] Ctr Rech & Technol Energie, Lab Photovolta, BP 95,Technopole Borj Cedria, Hammam Lif 2050, Tunisia
[4] Univ Biskra Mohamed Khider, Lab Mol Chem & Environm, Biskra 07000, Algeria
[5] Univ El Oued Echahid Hamma Lakhdar, Dept Exact Sci, El Oued 07000, Algeria
[6] SRM Inst Sci & Technol, Dept Phys & Nanotechnol, Kattankulathur 603203, India
来源：
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS | 2022年 / 286卷
关键词：
Spike protein; SERS; Silver nanoparticles; Paper; Sensor; SILVER NANOPARTICLES; SARS-COV-2;
D O I：
10.1016/j.mseb.2022.115984
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Rapid investigation on the detection of spike protein with paper sensor is projected with Surface Enhanced Raman Spectroscopy (SERS). SERS sensor with lab on paper is preceded with facile, cost-effective strategy. Silver nanoparticles with average size of 20-30 nm were produced by green chemistry approaches, followed by loading the nanoparticles on hydrophobic paper surfaces. The very low %RSD (similar to 1.5) with mapping scan ensembles high reproducibility. Spike protein detection analysis derived the prominent finger print regions of amide bands as well abundant amnio acids (Phenylalanine-1003 cm(-1), Tryptophan- 680 cm(-1), Tyrosine-1473 cm(-1)) respectively. The detectability of sensor is gauged to be 2.4 pg /mu L. Real time analysis on human saliva spiked with spike protein exhibited diagnosis within 2 min. Developed paper sensor provide us the scope of SERS technique to bring state of art in early detection of covid infections and safe disposal after its use.
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页数：7
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