The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

被引：46
作者：
Bredel, M [1 ]
Pollak, IF
机构：
[1] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Inst Canc, Brain Tumor Ctr, Pittsburgh, PA 15261 USA
来源：
BRAIN RESEARCH REVIEWS | 1999年 / 29卷 / 2-3期
关键词：
apoptosis; astrocytoma; cell proliferation; farnesyltransferase; geranylgeranyltransferase; glioblastoma multiforme; glioma growth; growth factor; growth inhibition; high-grade glioma; p21-Ras overactivation; mutation; signal transduction;
D O I：
10.1016/S0165-0173(98)00057-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high-grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：232 / 249
页数：18
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