The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

被引：46
作者：
Bredel, M [1 ]
Pollak, IF
机构：
[1] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Inst Canc, Brain Tumor Ctr, Pittsburgh, PA 15261 USA
来源：
BRAIN RESEARCH REVIEWS | 1999年 / 29卷 / 2-3期
关键词：
apoptosis; astrocytoma; cell proliferation; farnesyltransferase; geranylgeranyltransferase; glioblastoma multiforme; glioma growth; growth factor; growth inhibition; high-grade glioma; p21-Ras overactivation; mutation; signal transduction;
D O I：
10.1016/S0165-0173(98)00057-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high-grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：232 / 249
页数：18
相关论文
共 258 条
[1]   GROWTH-FACTORS AND CANCER [J].
AARONSON, SA .
SCIENCE, 1991, 254 (5035) :1146-1153
[2]  
AARONSON SA, 1993, ADV EXP MED BIOL, V348, P7
[3]  
ADLER V, 1992, J BIOL CHEM, V267, P17001
[4]   Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120(GAP) and neurofibromin [J].
Ahmadian, MR ;
Wiesmuller, L ;
Lautwein, A ;
Bischoff, FR ;
Wittinghofer, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (27) :16409-16415
[5]   IDENTIFICATION OF THE SITES IN MAP KINASE KINASE-1 PHOSPHORYLATED BY P74(RAF-1) [J].
ALESSI, DR ;
SAITO, Y ;
CAMPBELL, DG ;
COHEN, P ;
SITHANANDAM, G ;
RAPP, U ;
ASHWORTH, A ;
MARSHALL, CJ ;
COWLEY, S .
EMBO JOURNAL, 1994, 13 (07) :1610-1619
[6]   BINDING OF THE RAS ACTIVATOR SON OF SEVENLESS TO INSULIN-RECEPTOR SUBSTRATE-1 SIGNALING COMPLEXES [J].
BALTENSPERGER, K ;
KOZMA, LM ;
CHERNIACK, AD ;
KLARLUND, JK ;
CHAWLA, A ;
BANERJEE, U ;
CZECH, MP .
SCIENCE, 1993, 260 (5116) :1950-1952
[7]   ECONOMIC-ASPECTS OF TROPICAL DEFORESTATION IN SOUTHEAST-ASIA [J].
BARBIER, EB .
GLOBAL ECOLOGY AND BIOGEOGRAPHY, 1993, 3 (4-6) :215-234
[8]  
Barnard D, 1995, ONCOGENE, V10, P1283
[9]  
BIGNER SH, 1988, CANCER RES, V48, P405
[10]   SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK [J].
BLENIS, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5889-5892
12345678910