Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications

被引：142
作者：
Ranganathan, Ramya [1 ]
Madanmohan, Shruthilaya [1 ]
Kesavan, Akila [1 ]
Baskar, Ganga [1 ]
Krishnamoorthy, Yoganathan Ramia [2 ]
Santosham, Roy [3 ]
Ponraju, D. [4 ]
Rayala, Suresh Kumar [2 ]
Venkatraman, Ganesh [1 ]
机构：
[1] Sri Ramachandra Univ, Dept Human Genet, Madras 600116, Tamil Nadu, India
[2] Indian Inst Technol, Dept Biotechnol, Madras 600036, Tamil Nadu, India
[3] Sri Ramachandra Univ, Dept Radiol & Imaging Sci, Madras 600116, Tamil Nadu, India
[4] Indira Gandhi Ctr Atom Res, Safety Engn Div, Nucl & Engn Safety Grp, Kalpakkam 603102, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2012年 / 7卷
关键词：
patient-friendly; drug-delivery systems; cancer; nanomedicine; POLYETHYLENE-GLYCOL-LIPOSOMES; FOLATE-RECEPTOR; IN-VITRO; CYANOACRYLATE) NANOPARTICLES; MAGNETIC NANOPARTICLES; CLINICAL-APPLICATIONS; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; CANCER CELLS; IRON-OXIDE;
D O I：
10.2147/IJN.S25182
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The focus on nanotechnology in cancer treatment and diagnosis has intensified due to the serious side effects caused by anticancer agents as a result of their cytotoxic actions on normal cells. This nonspecific action of chemotherapy has awakened a need for formulations capable of definitive targeting with enhanced tumor-killing. Nanooncology, the application of nanobiotechnology to the management of cancer, is currently the most important area of nanomedicine. Currently several nanomaterial-based drug-delivery systems are in vogue and several others are in various stages of development. Tumor-targeted drug-delivery systems are envisioned as magic bullets for cancer therapy and several groups are working globally for development of robust systems.
引用
收藏
页码：1043 / 1060
页数：18
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