Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

被引：67

作者：

Burchat, A ^{[1
]}

Borhani, DW ^{[1
]}

Calderwood, DJ ^{[1
]}

Hirst, GC ^{[1
]}

Li, BQ ^{[1
]}

Stachlewitz, RF ^{[1
]}

机构：

[1] Abbott Biores Ctr, Worcester, MA 01605 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

lck inhibitor; src-family; transplant rejection; kinase inhibitor;

D O I：

10.1016/j.bmcl.2005.09.039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the identification, SAR, and pharmacology of the src-family selective Ick inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：118 / 122

页数：5

共 7 条

[1] A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection [J].