Total synthesis of (±)-cis-5-hydroxycalamenene

被引：1
|
作者：
Ng, Po S. Poon [1 ]
Banerjee, Ajoy K. [1 ]
机构：
[1] Inst Venezolano Invest Cient, Ctr Quim, Caracas 1020A, Venezuela
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 13期
关键词：
(+/-)-cis-5-hydroxycalamenene; Grignard reaction; 5-methoxy-alpha-tetralone; terpene;
D O I：
10.1080/00397910802026204
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A total synthesis of (+/-)-cis-5-hydroxycalamenene 1 has been achieved from tetralone 5, which in turn was prepared from 5-methoxy-alpha-tetralone 3. Grignard reaction of compound 5 with isopropylmagnesium chloride, followed by dehydration and aromatization, provided the substituted naphthalene 7 whose conversion to (+/-)-cis-5-hydroxycalamenene 1 was accomplished by demethylation, formylation, and hydrogenation.
引用
收藏
页码：2261 / 2268
页数：8
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