MicroRNAs in Stress Signaling and Human Disease

被引：1479

作者：

Mendell, Joshua T. ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

CELL | 2012年 / 148卷 / 06期

基金：

美国国家卫生研究院;

关键词：

SMALL RNAS; GENE-EXPRESSION; MIR-17-SIMILAR-TO-92; CLUSTER; CARDIAC-HYPERTROPHY; CELL-PROLIFERATION; SLITRK1; GENE; TARGET SITE; LUNG-CANCER; IN-VIVO; FAMILY;

D O I：

10.1016/j.cell.2012.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

引用

页码：1172 / 1187

页数：16

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