Diffuse large B-cell lymphoma in the primary bone marrow

被引：7

作者：

Hu, Y. ^{[1
]}

Chen, S. L. ^{[1
]}

Huang, Z. X. ^{[1
]}

Gao, W. ^{[1
]}

An, N. ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Hematol, Beijing, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 02期

关键词：

Bone marrow; Diffuse large B-cell lymphoma;

D O I：

10.4238/2015.June.9.10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study aimed to improve understanding of the diagnosis, treatment, and prognosis of primary bone marrow (PBM) diffuse large B-cell lymphoma (DLBCL), a rare illness. We report a 56-year-old man with pancytopenia and hyperbilirubinemia but without lymphadenopathy, hepatomegaly, or splenomegaly. Bone marrow aspiration, flow cytometry, biopsy, and immunohistochemistry confirmed DLBCL. Two cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone were administered. Blood cell numbers and hyperbilirubinemia improved. Although the patient did not completely recover, he survived for at least 3 years after chemotherapy and receiving blood transfusions. PBM DLBCL is a distinct, aggressive lymphoma characterized by lymphoma cells only in the bone marrow and effectively treated via chemotherapy. Prognoses for PBM DLBCL vary.

引用

页码：6247 / 6250

页数：4

共 10 条

[1] Isolated bone marrow involvement in diffuse large B cell lymphoma: A report of three cases with review of morphological, immunophenotypic and cytogenetic findings [J].

Alvares, CL ;

Matutes, E ;

Scully, MA ;

Swansbury, J ;

Min, T ;

Gruszka-Westwood, AM ;

Atkinson, S ;

Hilditch, B ;

Morilla, R ;

Wotherspoon, AC ;

Catovsky, D .

LEUKEMIA & LYMPHOMA, 2004, 45 (04) :769-775

[2] Primary bone marrow diffuse large B cell lymphoma: a case series and review [J].

Chang, Hung ;

Hung, Yu-Shin ;

Lin, Tung-Liang ;

Wang, Po-Nan ;

Kuo, Ming-Chung ;

Tang, Tzung-Chih ;

Wu, Jin-Hou ;

Dunn, Po ;

Shih, Lee-Yung .

ANNALS OF HEMATOLOGY, 2011, 90 (07) :791-796

[3] A database on cytogenetics in haematology and oncology [J].

Dorkeld, F ;

Bernheim, A ;

Dessen, P ;

Huret, JL .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :353-354

[4]

Hishizawa Masakatsu, 2007, Br J Haematol, V136, P351, DOI 10.1111/j.1365-2141.2006.06336.x

[5] A Case of Primary Bone Marrow B-Cell Non Hodgkin's Lymphoma with Severe Thrombocytopenia: Case Report and A Review of the Literature [J].

Kagoya, Yuki ;

Sahara, Naohi ;

Matsunaga, Takashi ;

Uekusa, Toshimasa ;

Irie, Seiji ;

Hatanaka, Kazuhito .

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2010, 26 (03) :106-108

[6] Diffuse large B-cell lymphoma initially manifesting in the bone marrow [J].

Kajiura, Dai ;

Yamashita, Yoriko ;

Mori, Naoyoshi .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2007, 127 (05) :762-769

[7] Long-TermRemission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells [J].

Kazama, Hiroshi ;

Teramura, Masanao ;

Yoshinaga, Kentaro ;

Masuda, Akihiro ;

Motoji, Toshiko .

CASE REPORTS IN MEDICINE, 2012, 2012

[8]

Strauchen JA, 2003, MT SINAI J MED, V70, P133

[9]

Sumi Masahiko, 2007, Rinsho Ketsueki, V48, P571

[10]

Yoshida Katsuhiko, 2002, Rinsho Ketsueki, V43, P943

← 1 →