Candida auris: Epidemiology, risk factors, virulence, resistance, and therapeutic options

被引：92

作者：

Orlandi Sardi, Janaina de Cassia ^{[1
]}

Silva, Diego Romario ^{[1
]}

Soares Mendes-Giannini, Maria Jose ^{[2
]}

Rosalen, Pedro Luiz ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Physiol Sci, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, Brazil

[2] Sao Paulo State Univ UNESP, Dept Clin Anal, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil

来源：

MICROBIAL PATHOGENESIS | 2018年 / 125卷

关键词：

Candida auris; Resistance; Virulence factor; FLIGHT MASS-SPECTROMETRY; CHANGING EPIDEMIOLOGY; HISTORICAL TRENDS; FUNGAL-INFECTIONS; BIOFILM FORMATION; IONIZATION-TIME; 1ST REPORT; IDENTIFICATION; DISINFECTANTS; MULTICENTER;

D O I：

10.1016/j.micpath.2018.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida awls emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan. The difficulty in identification, incorrect use of antifungal drugs, and treatment failure are causes of high mortality. Since then, C. auris has been increasingly reported from East Asia to North America, with substantial fatalities and misidentification. This review aims at describing the epidemiology, virulence, risk factors, resistance, and therapeutic options in C. auris infections.

引用

页码：116 / 121

页数：6

共 56 条

[1] In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris [J].

Abdolrasouli, Alireza ;

Armstrong-James, Darius ;

Ryan, Lisa ;

Schelenz, Silke .

MYCOSES, 2017, 60 (11) :758-763

[2] First report of Candida auris in Oman: Clinical and microbiological description of five candidemia cases [J].

Al-Siyabi, Turkiya ;

Al Busaidi, Ibrahim ;

Balkhair, Abdullah ;

Al-Muharrmi, Zakariya ;

Al-Salti, Maya ;

Al'Adawi, Badriya .

JOURNAL OF INFECTION, 2017, 75 (04) :373-376

[3] Nosocomial Fungal Infections: Epidemiology, Infection Control, and Prevention [J].

Alangaden, George J. .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2011, 25 (01) :201-+

[4] Isolation of Candida auris from 9 patients in Central America: Importance of accurate diagnosis and susceptibility testing [J].

Arauz, Ana Belen ;

Caceres, Diego H. ;

Santiago, Erika ;

Armstrong, Paige ;

Arosemena, Susan ;

Ramos, Carolina ;

Espinosa-Bode, Andres ;

Borace, Jovanna ;

Hayer, Lizbeth ;

Cedeno, Israel ;

Jackson, Brendan R. ;

Sosa, Nestor ;

Berkow, Elizabeth L. ;

Lockhart, Shawn R. ;

Rodriguez-French, Amalia ;

Chiller, Tom .

MYCOSES, 2018, 61 (01) :44-47

[5] Multidrug-Resistant Candida haemulonii and C-auris, Tel Aviv, Israel [J].

Ben-Ami, Ronen ;

Berman, Judith ;

Novikov, Ana ;

Bash, Edna ;

Shachor-Meyouhas, Yael ;

Zakin, Shin ;

Maor, Yasmin ;

Tarabia, Jalal ;

Schechner, Vered ;

Adler, Amos ;

Finn, Talya .

EMERGING INFECTIOUS DISEASES, 2017, 23 (02) :195-203

[6]

Berkow E. L., 2017, VITRO ACTIVITY NOVEL

[7] In Vitro Activity of a Novel Glucan Synthase Inhibitor, SCY-078, against Clinical Isolates of Candida auris [J].

Berkow, Elizabeth L. ;

Angulo, David ;

Lockhart, Shawn R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (07)

[8]

Binder U, 2011, MEDITERR J HEMATOL I, V3, DOI [10.4084/MJHID.2011.0016, 10.4084/MJHID.2011.016]

[9] Comparative Pathogenicity of United Kingdom Isolates of the Emerging Pathogen Candida auris and Other Key Pathogenic Candida Species [J].

Borman, Andrew M. ;

Szekely, Adrien ;

Johnson, Elizabeth M. .

MSPHERE, 2016, 1 (04)

[10]

Brandt ME, 2012, CURR FUNGAL INFECT R, V6, P170, DOI 10.1007/s12281-012-0094-x

← 1 2 3 4 5 6 →