Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications

被引:104
|
作者
Wu, Qingzhi [1 ]
Cao, Huaqiang [1 ,3 ]
Luan, Qiuying [2 ]
Zhang, Jiyong [2 ]
Wang, Zhao [2 ]
Warner, Jamie H. [3 ]
Watt, Andrew A. R. [3 ]
机构
[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
[3] Univ Oxford, Dept Mat, Oxford OX1 3PH, England
关键词
D O I
10.1021/ic8002228
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The application of nanoparticles in the biomedical field is an exciting interdisciplinary research area in current materials science. In the present study, size-tunable and water-soluble noble metal silver nanoparticles (Ag NPs) have been successfully synthesized with the assistance of glutathione (GSH). The as-synthesized Ag NPs are ready to bind covalently with a model protein (bovine serum albumin) in mild conditions. The optical property of surface-modifiable Ag NPs was extremely sensitive to their size and the surface modification, suggesting a potential in the biomedical analysis and detection. Furthermore, Ag NPs with an average diameter of ca. 6 nm effectively suppress the proliferation of human leukemic K562 cells in the dose- and time-dependent manners, suggesting the promising potential of Ag NPs in cancer therapy.
引用
收藏
页码:5882 / 5888
页数:7
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