Chiral dihydroxytetraphenylene-catalyzed enantioselective conjugate addition of boronic acids to β-enaminones

被引：13
作者：
Yao, En-Ze [1 ]
Chai, Guo-Li [1 ]
Zhang, Ping [1 ]
Zhu, Bo [1 ]
Chang, Junbiao [1 ]
机构：
[1] Henan Normal Univ, Sch Chem & Chem Engn, NMPA Key Lab Res & Evaluat Innovat Drug, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 09期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC DARZENS REACTION; BOND-FORMING REACTIONS; ALKENYLBORONIC ACIDS; ARYLBORONIC ACIDS; ENONES; AMIDES; CONSTRUCTION; COMPLEXES; MOTUPORIN; CHEMISTRY;
D O I：
10.1039/d1qo01845k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report the (S)-2,15-Cl-2-DHTP-catalyzed enantioselective conjugate addition of organic boronic acids to beta-enaminones, providing the corresponding addition products in high yields and moderate to excellent enantioselectivities (up to 98% ee). This catalytic system exhibits unique features in terms of mild reaction conditions, high efficiency, broad substrate scope, and the applicability of alkenylboronic acids and heteroarylboronic acids.
引用
收藏
页码：2375 / 2381
页数：7
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