Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

被引：26

作者：

da Silva, Allan Ribeiro ^{[1
]}

dos Santos, Deborah Araujo ^{[1
,2
]}

Paixao, Marcio Weber ^{[1
]}

Correa, Arlene Goncalves ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Ctr Excellence Res Sustainable Chem, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13563120 Sao Carlos, SP, Brazil

来源：

MOLECULES | 2019年 / 24卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

multicomponent reactions; epoxides; aziridine; asymmetric synthesis; green synthesis; RING-EXPANSION CASCADE; ONE-POT SYNTHESIS; BETA-AMINO ACID; STEREOSPECIFIC SYNTHESIS; ASYMMETRIC-SYNTHESIS; 3-COMPONENT REACTION; ALDEHYDE DIMERS; CARBON-MONOXIDE; N-H; CATALYSIS;

D O I：

10.3390/molecules24030630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions.

引用

页数：23

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