Folic acid supplementation and chronic kidney disease progression

被引：11
作者：
Wyatt, Christina M. [1 ]
Spence, J. David [2 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA
[2] Western Univ, Stroke Prevent & Atherosclerosis Res Ctr, Robarts Res Inst, London, ON, Canada
来源：
KIDNEY INTERNATIONAL | 2016年 / 90卷 / 06期
关键词：
RANDOMIZED CONTROLLED-TRIAL; PREVENTION; MORTALITY; EFFICACY; VITAMINS; THERAPY; STROKE;
D O I：
10.1016/j.kint.2016.09.019
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In contrast to prior studies demonstrating no benefit or even increased harm from B vitamin supplementation in patients with chronic kidney disease, a large randomized trial from China recently demonstrated small but statistically significant reductions in the risk of first stroke and chronic kidney disease progression with the addition of folic acid to enalapril in adults with hypertension. Differences in the study population and study intervention may explain these discordant results. Refers to: Xu X, Qin X, Li Y, et al. Efficacy of folic acid therapy on the progression of chronic kidney disease. The renal substudy of the China Stroke Primary Prevention Trial. JAMA Intern Med. 2016;176:1443-1450. Copyright (C) 2016, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1144 / 1145
页数：2
相关论文
共 8 条
[1]   Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals [J].
Clarke, Robert ;
Halsey, Jim ;
Lewington, Sarah ;
Lonn, Eva ;
Armitage, Jane ;
Manson, JoAnn E. ;
Bonaa, Kaare H. ;
Spence, J. David ;
Nygard, Ottar ;
Jamison, Rex ;
Gaziano, J. Michael ;
Guarino, Peter ;
Bennett, Derrick ;
Mir, Fraz ;
Peto, Richard ;
Collins, Rory .
ARCHIVES OF INTERNAL MEDICINE, 2010, 170 (18) :1622-1631
[2]   Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy A Randomized Controlled Trial [J].
House, Andrew A. ;
Eliasziw, Misha ;
Cattran, Daniel C. ;
Churchill, David N. ;
Oliver, Matthew J. ;
Fine, Adrian ;
Dresser, George K. ;
Spence, J. David .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (16) :1603-1609
[3]   Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China The CSPPT Randomized Clinical Trial [J].
Huo, Yong ;
Li, Jianping ;
Qin, Xianhui ;
Huang, Yining ;
Wang, Xiaobin ;
Gottesman, Rebecca F. ;
Tang, Genfu ;
Wang, Binyan ;
Chen, Dafang ;
He, Mingli ;
Fu, Jia ;
Cai, Yefeng ;
Shi, Xiuli ;
Zhang, Yan ;
Cui, Yimin ;
Sun, Ningling ;
Li, Xiaoying ;
Cheng, Xiaoshu ;
Wang, Jian'an ;
Yang, Xinchun ;
Yang, Tianlun ;
Xiao, Chuanshi ;
Zhao, Gang ;
Dong, Qiang ;
Zhu, Dingliang ;
Wang, Xian ;
Ge, Junbo ;
Zhao, Lianyou ;
Hu, Dayi ;
Liu, Lisheng ;
Hou, Fan Fan .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (13) :1325-1335
[4]   Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease - A randomized controlled trial [J].
Jamison, Rex L. ;
Hartigan, Pamela ;
Kaufman, James S. ;
Goldfarb, David S. ;
Warren, Stuart R. ;
Guarino, Peter D. ;
Gaziano, J. Michael .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (10) :1163-1170
[5]  
Jardine MJ, 2012, BMJ-BRIT MED J, V13
[6]   Understanding the Complexity of Homocysteine Lowering With Vitamins The Potential Role of Subgroup Analyses [J].
Spence, J. David ;
Stampfer, Meir J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (23) :2610-2611
[7]   Efficacy of folic acid supplementation in stroke prevention: a meta-analysis [J].
Wang, Xiaobin ;
Qin, Xianhui ;
Demirtas, Hakan ;
Li, Jianping ;
Mao, Guangyun ;
Huo, Yong ;
Sun, Ningling ;
Liu, Lisheng ;
Xu, Xiping .
LANCET, 2007, 369 (9576) :1876-1882
[8]   Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease The Renal Substudy of the China Stroke Primary Prevention Trial [J].
Xu, Xin ;
Qin, Xianhui ;
Li, Youbao ;
Sun, Danhua ;
Wang, Jun ;
Liang, Min ;
Wang, Binyan ;
Huo, Yong ;
Hou, Fan Fan .
JAMA INTERNAL MEDICINE, 2016, 176 (10) :1443-1450
1