Synthesis of Polysubstituted Pyrroles through the Tandem 1,3-Addition/5-endo-dig Cyclization of 1-(1-Alkynyl)cyclopropyl Imines

被引：14

作者：

Urbanaite, Aurelija ^{[1
]}

Cikotiene, Inga ^{[1
]}

机构：

[1] Vilnius Univ, Dept Organ Chem, Fac Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 31期

关键词：

Alkynes; Small-ring systems; Cyclization; Nitrogen heterocycles; Imines; HIGHLY SUBSTITUTED FURANS; NATURAL-PRODUCTS; ELECTROPHILIC CYCLIZATION; MODULAR ENTRY; 1-(1-ALKYNYL)-CYCLOPROPYL KETONES; CYCLOADDITION REACTIONS; BIOLOGICAL-ACTIVITY; NITRONES; ALKYNES; NUCLEOPHILES;

D O I：

10.1002/ejoc.201600985

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclopropyl-tethered 3-alkynyl imines react with polarized-covalent-bond-containing compounds to give polyfunctionalized pyrroles. This provides a mild and effective method for the simultaneous introduction of halogen, chalcogen, or hydrogen groups to the 3-position of the pyrrole ring, together with the incorporation of halogen, azide, or alkoxy/aryloxy groups into the ethyl side-chain.

引用

页码：5294 / 5300

页数：7

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