Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients

被引:36
作者
Garcia-Leon, Juan A. [1 ,2 ]
Pinto-Medel, Maria J. [1 ,2 ]
Garcia-Trujillo, Lucia [3 ]
Lopez-Gomez, Carlos [1 ,2 ]
Oliver-Martos, Begona [1 ,2 ]
Prat-Arrojo, Isidro [4 ]
Marin-Banasco, Carmen [1 ,2 ]
Suardiaz-Garcia, Margarita [1 ,2 ]
Maldonado-Sanchez, Rafael [1 ,2 ]
Fernandez-Fernandez, Oscar [3 ]
Leyva-Fernandez, Laura [1 ,2 ]
机构
[1] Carlos Haya Reg Univ Hosp, Res Lab, Clin Neurosci Inst, Malaga 29009, Spain
[2] Hosp Civil, Fdn IMABIS, Malaga 29009, Spain
[3] Carlos Haya Reg Univ Hosp, Dept Neurol, Clin Neurogenet Inst, Malaga 29010, Spain
[4] Transfus Ctr, Blood Bank, Malaga 29009, Spain
关键词
Killer immunoglobulin-like receptors (KIRs); Multiple sclerosis; HLA-class I; Immune diversity; Autoimmunity; Susceptibility genes; SEQUENCE-SPECIFIC PRIMERS; HLA-B; KIR; SUSCEPTIBILITY; POLYMORPHISMS; SELECTION; GENETICS; ALLELES; DISEASE; KIR2DL5;
D O I
10.1016/j.molimm.2011.05.018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases, but their role in multiple sclerosis (MS) is still unclear. Here we determined the influence of KIR genes and their HLA class I ligands on susceptibility to MS and on the response to interferon-beta treatment in a Spanish population. KIR and HLA genotyping were performed in 200 MS patients and 200 controls. Significantly higher frequencies were found for KIR2DL5 and KIR3DS1 genes in MS patients and the carriage of the KIR2DL1 gene was associated with a higher progression index. Moreover, the frequency of the HL4-Bw4 motif was significantly reduced in MS patients. The KIR2DL1 and HLA-C2 matches were more frequent in MS patients, whereas the KIR3DL1 and HLA-Bw4 matches were more frequent in healthy controls. Nevertheless, non significant associations were found between all the KIR genes and therapeutic response to interferon-beta. Our results confirm that the carriage of HL4-Bw4 is a protective factor in MS and suggest that KIR2DL5 and KIR3DS1 may have a predisposing role in the disease. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1896 / 1902
页数:7
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