Moving targets: Emerging roles for MMPs in cancer progression and metastasis

被引：338

作者：

Shay, Gemma ^{[1
]}

Lynch, Conor C. ^{[1
]}

Fingleton, Barbara ^{[2
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, Tampa, FL 33612 USA

[2] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA

来源：

MATRIX BIOLOGY | 2015年 / 44-46卷

基金：

美国国家卫生研究院;

关键词：

Non-catalytic; Imaging; Activity-based probe; Theranostic; Efficacy; Pre-metastatic niche; Therapy; ACTIVITY IN-VIVO; MATRIX-METALLOPROTEINASE INHIBITORS; BONE-MARROW; BRANCHING MORPHOGENESIS; NONINVASIVE DETECTION; MEMBRANE; MT1-MMP; CELLS; EXPRESSION; PROBE;

D O I：

10.1016/j.matbio.2015.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a variety of tumor types. Here, we discuss some of the newer roles that have been uncovered for MMPs in cancer that would not have been targeted with those initial inhibitors or in the patient populations analyzed. We also consider novel ways of using cancer-associated MMP activity for clinical benefit. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：200 / 206

页数：7

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