A Concise Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 8

被引：28

作者：

Visansirikul, Satsawat ^{[1
]}

Yasomanee, Jagodige P. ^{[1
]}

Pornsuriyasak, Papapida ^{[1
]}

Kamat, Medha N. ^{[1
]}

Podvalnyy, Nikita M. ^{[1
]}

Gobble, Chase P. ^{[1
]}

Thompson, Melissa ^{[2
]}

Kolodziej, Stephen A. ^{[3
]}

Demchenko, Alexei V. ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA

[2] Pfizer Inc, Analyt R&D, Biotherapeut Pharmaceut Sci, Chesterfield, MO 63017 USA

[3] Pfizer Inc, Bioproc R&D, Biotherapeut Pharmaceut Sci, Chesterfield, MO 63017 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 10期

关键词：

GLYCOSYLATION; FUCOSAMINE; GLYCOSIDES; CHEMISTRY; EFFICIENT; VACCINES;

D O I：

10.1021/acs.orglett.5b00899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of the repeating unit of S. aureus capsular polysaccharide type 8 is described. The repeating unit is an unusual trisaccharide sequence of three uncommon sugars, all connected via 1,2-cis linkages. The synthetic trisaccharide was equipped with capping methyl groups at the points of propagation of the polysaccharide sequence.

引用

页码：2382 / 2384

页数：3

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