High prevalence of genotype 4 among hepatitis C virus-infected intravenous drug users in north-eastern Poland

被引：15

作者：

Chlabicz, S. ^{[1
]}

Flisiak, R. ^{[2
]}

Kowalczuk, O. ^{[3
]}

Wiercinska-Drapalo, A. ^{[2
]}

Pytel-Krolczuk, B. ^{[1
]}

Prokopowicz, D. ^{[2
]}

Chyczewski, L. ^{[3
]}

机构：

[1] Dept Family Med & Community Nursing, PL-15054 Bialystok, Poland

[2] Med Univ Bialystok, Dept Infect Dis, Bialystok, Poland

[3] Med Univ Bialystok, Dept Clin Mol Biol, Bialystok, Poland

来源：

JOURNAL OF MEDICAL VIROLOGY | 2008年 / 80卷 / 04期

关键词：

genotype; Hepacivirus; hepatitis C; intravenous; substance abuse;

D O I：

10.1002/jmv.21107

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this study was to describe the distribution of hepatitis C genotypes among intravenous drug users in north-eastern Poland. The study group included intravenous drug users recruited at a drug treatment center and a clinic for HIV-infected patients. HCV infection was confirmed by qualitative nested RT-PCR to test for the presence of HCV RNA. Genotypes were determined by 5'UTR sequencing and comparing the results with known genotype sequences. Among 111 HCV-infected and HCV-RNA-positive intravenous drug users, the most prevalent genotypes were 1 (38.7%), 3 (37.8%), and 4 (23.4%). Most infections with genotype 4 (88.5%) were found among HCV-HIV-coinfected drug users. The study demonstrated a high prevalence of genotype 4 (23.4%) among HCV-infected Polish drug users.

引用

页码：615 / 618

页数：4

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