High prevalence of genotype 4 among hepatitis C virus-infected intravenous drug users in north-eastern Poland

被引：15
作者：
Chlabicz, S. [1 ]
Flisiak, R. [2 ]
Kowalczuk, O. [3 ]
Wiercinska-Drapalo, A. [2 ]
Pytel-Krolczuk, B. [1 ]
Prokopowicz, D. [2 ]
Chyczewski, L. [3 ]
机构：
[1] Dept Family Med & Community Nursing, PL-15054 Bialystok, Poland
[2] Med Univ Bialystok, Dept Infect Dis, Bialystok, Poland
[3] Med Univ Bialystok, Dept Clin Mol Biol, Bialystok, Poland
来源：
JOURNAL OF MEDICAL VIROLOGY | 2008年 / 80卷 / 04期
关键词：
genotype; Hepacivirus; hepatitis C; intravenous; substance abuse;
D O I：
10.1002/jmv.21107
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aim of this study was to describe the distribution of hepatitis C genotypes among intravenous drug users in north-eastern Poland. The study group included intravenous drug users recruited at a drug treatment center and a clinic for HIV-infected patients. HCV infection was confirmed by qualitative nested RT-PCR to test for the presence of HCV RNA. Genotypes were determined by 5'UTR sequencing and comparing the results with known genotype sequences. Among 111 HCV-infected and HCV-RNA-positive intravenous drug users, the most prevalent genotypes were 1 (38.7%), 3 (37.8%), and 4 (23.4%). Most infections with genotype 4 (88.5%) were found among HCV-HIV-coinfected drug users. The study demonstrated a high prevalence of genotype 4 (23.4%) among HCV-infected Polish drug users.
引用
收藏
页码：615 / 618
页数：4
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