IFITM, a common barrier to many viruses

被引：5
作者：
Tartour, Kevin
Cimarelli, Andrea [1 ]
机构：
[1] CIRI, F-69364 Lyon, France
来源：
M S-MEDECINE SCIENCES | 2015年 / 31卷 / 04期
关键词：
INDUCED TRANSMEMBRANE PROTEIN-3; INHIBITS HIV-1 INFECTION; INFLUENZA-A VIRUS; ANTIVIRAL ACTIVITY; S-PALMITOYLATION; DENGUE VIRUS; INTERFERON; ENTRY; RESTRICTION; SAMHD1;
D O I：
10.1051/medsci/20153104011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
During evolution, organisms developed adaptative mechanisms to survive continuous aggressions from a variety of pathogens. Among these lines of defence, many cellular proteins have been described to modulate viral replication and are the subject of intense study. This review will focus on IFITM (interferon induced transmembrane protein), a family of proteins that act against a particularly wide range of viruses. We will summarize our knowledge of the antiviral mechanisms used by IFITM to interfere with the replication of several viruses, and more specifically HIV (human immunodeficiency virus).
引用
收藏
页码：377 / 382
页数：6
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