The dark side of C5A in sepsis

被引：346
作者：
Ward, PA [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1269
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sepsis is a major clinical problem for which therapeutic interventions have been largely unsuccessful, in spite of promising strategies that were successful in animals, especially rodents. There is new evidence that sepsis causes excessive activation of the complement system and that this induces paralysis of innate immune functions in phagocytic cells due to effects of the powerful complement-activation product, C5a. This review describes our present understanding of how and why sepsis is a life-threatening condition and how it might be more effectively treated.
引用
收藏
页码：133 / 142
页数：10
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