A CD44-targeted Cu(ii) delivery 2D nanoplatform for sensitized disulfiram chemotherapy to triple-negative breast cancer

被引：38

作者：

Gao, Zhiguo ^{[1
]}

Li, Yaojia ^{[1
]}

Zhang, Yu ^{[1
]}

An, Peijing ^{[1
]}

Chen, Fanghui ^{[1
]}

Chen, Jian ^{[1
]}

You, Chaoqun ^{[2
]}

Wang, Zhifei ^{[1
]}

Sun, Baiwang ^{[1
]}

机构：

[1] Southeast Univ, Sch Chem & Chem Engn, Nanjing 210089, Peoples R China

[2] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China

来源：

NANOSCALE | 2020年 / 12卷 / 15期

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC FRAMEWORKS; DRUG; DOXORUBICIN; STABILITY; THERAPY; CELLS;

D O I：

10.1039/d0nr00434k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent studies have suggested that the anticancer activity of disulfiram (DSF, an FDA-approved alcohol-abuse drug) is Cu-dependent. Low system toxicity and explicit pharmacokinetic characteristics of DSF necessitate safe and effective Cu supplementation in local lesion for further applications. Herein, we presented a new conceptual 'nanosized coordination transport' strategy of Cu(ii) that was realized in porphyrin-based metal-organic frameworks, Sm-TCPP, with strong binding ability to Cu(ii) due to their coordination interactions. Sm-TCPP(Cu) was coated by hyaluronic acid (HA) that termed by Sm-TCPP(Cu)@HA, acting as 'beneficial horse' to target the tumor-localized HA receptor (CD44), thus liberating Cu(ii) ions in cellular overexpressed reductants. The CD44-mediated Cu(ii) accumulation efficiency of Sm-TCPP(Cu)@HA was benchmarked in vitro and vivo against the free TCPP (Cu) via ICP-MS analysis. More importantly, the sensitization effects of Sm-TCPP(Cu)@HA on the anticancer activity of DSF were demonstrated in vivo and in vitro. This study offered a new class of targeted Cu supplements to sensitize DSF for the effective treatment of cancer and established a versatile methodology for constructing a safe and specific delivery of metal ions within living organisms.

引用

页码：8139 / 8146

页数：8

共 30 条

[1] Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells [J].

Aires, Antonio ;

Ocampo, Sandra M. ;

Simoes, Bruno M. ;

Josefa Rodriguez, Maria ;

Cadenas, Jael F. ;

Couleaud, Pierre ;

Spence, Katherine ;

Latorre, Alfonso ;

Miranda, Rodolfo ;

Somoza, Alvaro ;

Clarke, Robert B. ;

Carrascosa, Jose L. ;

Cortajarena, Aitziber L. .

NANOTECHNOLOGY, 2016, 27 (06)

[2] Neutral and ionic platinum compounds containing a cyclometallated chiral primary amine: synthesis, antitumor activity, DNA interaction and topoisomerase I-cathepsin B inhibition [J].

Albert, Joan ;

Bosque, Ramon ;

Crespo, Margarita ;

Granell, Jaume ;

Lopez, Concepcion ;

Martin, Raquel ;

Gonzalez, Asensio ;

Jayaraman, Anusha ;

Quirante, Josefina ;

Calvis, Carme ;

Badia, Josefa ;

Baldoma, Laura ;

Font-Bardia, Merce ;

Cascante, Marta ;

Messeguer, Ramon .

DALTON TRANSACTIONS, 2015, 44 (30) :13602-13614

[3] Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer [J].

Allensworth, Jennifer L. ;

Evans, Myron K. ;

Bertucci, Francois ;

Aldrich, Amy J. ;

Festa, Richard A. ;

Finetti, Pascal ;

Ueno, Naoto T. ;

Safi, Rachid ;

McDonnell, Donald P. ;

Thiele, Dennis J. ;

Van Laereg, Steven ;

Devi, Gayathri R. .

MOLECULAR ONCOLOGY, 2015, 9 (06) :1155-1168

[4] Photothermal-Enhanced Inactivation of Glutathione Peroxidase for Ferroptosis Sensitized by an Autophagy Promotor [J].

An, Peijing ;

Gao, Zhiguo ;

Sun, Kai ;

Gu, Dihai ;

Wu, Hongshuai ;

You, Chaoqun ;

Li, Yaojia ;

Cheng, Kaiwu ;

Zhang, Yu ;

Wang, Zhifei ;

Sun, Baiwang .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (46) :42988-42997

[5] (Metallo)porphyrins as Potent Phototoxic Anti-Cancer Agents after Irradiation with Red Light [J].

Antoni, Philipp M. ;

Naik, Anu ;

Albert, Ina ;

Rubbiani, Riccardo ;

Gupta, Susmita ;

Ruiz-Sanchez, Pilar ;

Munikorn, Pornkanok ;

Mateos, Jose M. ;

Luginbuehl, Vera ;

Thamyongkit, Patchanita ;

Ziegler, Urs ;

Gasser, Gilles ;

Jeschke, Gunnar ;

Spingler, Bernhard .

CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (03) :1179-1183

[6]

Bush AI, 2008, J ALZHEIMERS DIS, V15, P223

[7] Self-Supporting Metal-Organic Layers as Single-Site Solid Catalysts [J].

Cao, Lingyun ;

Lin, Zekai ;

Peng, Fei ;

Wang, Weiwei ;

Huang, Ruiyun ;

Wang, Cheng ;

Yan, Jiawei ;

Liang, Jie ;

Zhang, Zhiming ;

Zhang, Teng ;

Long, Lasheng ;

Sun, Junliang ;

Lin, Wenbin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (16) :4962-4966

[8] A new zirconium inorganic building brick forming metal organic frameworks with exceptional stability [J].

Cavka, Jasmina Hafizovic ;

Jakobsen, Soren ;

Olsbye, Unni ;

Guillou, Nathalie ;

Lamberti, Carlo ;

Bordiga, Silvia ;

Lillerud, Karl Petter .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (42) :13850-13851

[9] Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity [J].

Chen, Di ;

Cui, Qiuzhi Cindy ;

Yang, Huanjie ;

Dou, Q. Ping .

CANCER RESEARCH, 2006, 66 (21) :10425-10433

[10] Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation [J].

Crouch, Peter J. ;

Hung, Lin Wai ;

Adlard, Paul A. ;

Cortes, Mikhalina ;

Lal, Varsha ;

Filiz, Gulay ;

Perez, Keyla A. ;

Nurjono, Milawaty ;

Caragounis, Aphrodite ;

Du, Tai ;

Laughton, Katrina ;

Volitakis, Irene ;

Bush, Ashley I. ;

Li, Qiao-Xin ;

Masters, Colin L. ;

Cappai, Roberto ;

Cherny, Robert A. ;

Donnelly, Paul S. ;

White, Anthony R. ;

Barnham, Kevin J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (02) :381-386

← 1 2 3 →