Synthesis, characterization and in vitro drug release of magnetic N-benzyl-O-carboxymethylchitosan nanoparticles loaded with indomethacin

被引:38
作者
Debrassi, Aline [1 ]
Buerger, Cristiani [1 ]
Rodrigues, Clovis Antonio [1 ]
Nedelko, Nataliya [2 ]
Slawska-Waniewska, Anna [2 ]
Dluzewski, Piotr [2 ]
Sobczak, Kamil [2 ]
Greneche, Jean-Marc [3 ]
机构
[1] Univ Vale Itajai, NIQFAR CCS, BR-88302202 Itajai, SC, Brazil
[2] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland
[3] Univ Maine, Lab Phys Etat Condense, UMR CNRS 6087, F-72085 Le Mans, France
关键词
Chitosan; Drug delivery; Indomethacin; Magnetic nanoparticles; Magnetic drug targeting; DELIVERY; MICROPARTICLES; MICROSPHERES; ADSORPTION; PARTICLES; HYDROGEL; POLYMERS; CELLS;
D O I
10.1016/j.actbio.2011.05.001
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Magnetic N-benzyl-O-carboxymethylchitosan nanoparticles were synthesized through incorporation and in situ methods and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and magnetization measurements. Indomethacin was incorporated into the nanoparticles via the solvent evaporation method. The indomethacin-loaded magnetic nanoparticles were characterized by the same techniques, and also by transmission electron microscopy. The nanoparticles containing the polymer showed a drug loading efficiency of between 60.8% and 74.8%, and the magnetic properties were not significantly affected by incorporation of the drug. The in vitro drug release study was carried out in simulated body fluid, pH 7.4 at 37 degrees C. The profiles showed an initial fast release, which became slower as time progressed. The percentage of drug released after 5 h was between 60% and 90%, and the best fitting mathematical model for drug release was the Korsmeyer-Peppas model, indicating a Fickian diffusion mechanism. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:3078 / 3085
页数:8
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