Total synthesis of (-)-nakadomarin A

被引：57

作者：

Kyle, Andrew F. ^{[1
]}

Jakubec, Pavol ^{[1
]}

Cockfield, Dane M. ^{[2
]}

Cleator, Ed ^{[3
]}

Skidmore, John ^{[4
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] Univ Manchester, Sch Chem, Manchester, Lancs, England

[3] Merck Sharp Dohme Res Labs, Hoddesdon EN11 9BU, Herts, England

[4] GlaxoSmithKline, Neurosci Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 36期

基金：

英国工程与自然科学研究理事会;

关键词：

METAL-CARBON BONDS; NAKADOMARIN-A; STEREOSELECTIVE-SYNTHESIS; ALKYNE METATHESIS; TETRACYCLIC CORE; BIFUNCTIONAL ORGANOCATALYSTS; ACETYLENE METATHESIS; FORMAL SYNTHESIS; NITRO-GROUP; COMPLEXES;

D O I：

10.1039/c1cc13665h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furan N-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (-)-nakadomarin A.

引用

页码：10037 / 10039

页数：3

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