The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization

被引:337
作者
Davidson, DJ
Currie, AJ
Reid, GSD
Bowdish, DME
MacDonald, KL
Ma, RC
Hancock, REW
Speert, DP
机构
[1] British Columbia Res Inst Child & Family Hlth, Vancouver, BC V5Z 4H4, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada
关键词
D O I
10.4049/jimmunol.172.2.1146
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC.
引用
收藏
页码:1146 / 1156
页数:11
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