Prognostic Impact of Cerebral Small Vessel Disease on Stroke Outcome

被引：70
作者：
Kim, Beom Joon [1 ,2 ]
Leeb, Seung-Hoon [3 ]
机构：
[1] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Seoul, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Cerebrovasc Ctr, Seoul, South Korea
[3] Seoul Natl Univ Hosp, Dept Neurol, Seoul 110744, South Korea
来源：
JOURNAL OF STROKE | 2015年 / 17卷 / 02期
关键词：
Small vessel disease; White matter hyperintensity; Silent brain infarction; Cerebral microbleed; Prognosis; Outcome; WHITE-MATTER LESIONS; SILENT BRAIN INFARCTS; TRANSIENT ISCHEMIC ATTACK; LONG-TERM PROGNOSIS; INTRACEREBRAL HEMORRHAGE; RISK-FACTOR; LEUKOARAIOSIS PREDICTS; BLEEDING RISK; MICROBLEEDS; THROMBOLYSIS;
D O I：
10.5853/jos.2015.17.2.101
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cerebral small vessel disease (SVD), which includes white matter hyperintensities (WMHs), silent brain infarction (SBI), and cerebral microbleeds (CMBs), develops in a conjunction of cumulated injuries to cerebral microvascular beds, increased permeability of blood-brain barriers, and chronic oligemia. SVD is easily detected by routine neuroimaging modalities such as brain computed tomography or magnetic resonance imaging. Research has revealed that the presence of SVD markers may increase the risk of future vascular events as well as deteriorate functional recovery and neurocognitive trajectories after stroke, and such an association could also be applied to hemorrhagic stroke survivors. Currently, the specific mechanistic processes leading to the development and manifestation of SVD risk factors are unknown, and further studies with novel methodological tools are warranted. In this review, recent studies regarding the prognostic impact of WMHs, SBI, and CMBs on stroke survivors and briefly summarize the pathophysiological concepts underlying the manifestation of cerebral SVD.
引用
收藏
页码：101 / 110
页数：10
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