Prognostic Impact of Cerebral Small Vessel Disease on Stroke Outcome

被引：74

作者：

Kim, Beom Joon ^{[1
,2
]}

Leeb, Seung-Hoon ^{[3
]}

机构：

[1] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Seoul, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Cerebrovasc Ctr, Seoul, South Korea

[3] Seoul Natl Univ Hosp, Dept Neurol, Seoul 110744, South Korea

来源：

JOURNAL OF STROKE | 2015年 / 17卷 / 02期

关键词：

Small vessel disease; White matter hyperintensity; Silent brain infarction; Cerebral microbleed; Prognosis; Outcome; WHITE-MATTER LESIONS; SILENT BRAIN INFARCTS; TRANSIENT ISCHEMIC ATTACK; LONG-TERM PROGNOSIS; INTRACEREBRAL HEMORRHAGE; RISK-FACTOR; LEUKOARAIOSIS PREDICTS; BLEEDING RISK; MICROBLEEDS; THROMBOLYSIS;

D O I：

10.5853/jos.2015.17.2.101

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral small vessel disease (SVD), which includes white matter hyperintensities (WMHs), silent brain infarction (SBI), and cerebral microbleeds (CMBs), develops in a conjunction of cumulated injuries to cerebral microvascular beds, increased permeability of blood-brain barriers, and chronic oligemia. SVD is easily detected by routine neuroimaging modalities such as brain computed tomography or magnetic resonance imaging. Research has revealed that the presence of SVD markers may increase the risk of future vascular events as well as deteriorate functional recovery and neurocognitive trajectories after stroke, and such an association could also be applied to hemorrhagic stroke survivors. Currently, the specific mechanistic processes leading to the development and manifestation of SVD risk factors are unknown, and further studies with novel methodological tools are warranted. In this review, recent studies regarding the prognostic impact of WMHs, SBI, and CMBs on stroke survivors and briefly summarize the pathophysiological concepts underlying the manifestation of cerebral SVD.

引用

页码：101 / 110

页数：10

共 69 条

[1]

Avdibegovic E, 2007, PSYCHIAT DANUB, V19, P49

[2]

Bokura Hirokazu, 2006, J Stroke Cerebrovasc Dis, V15, P57, DOI 10.1016/j.jstrokecerebrovasdis.2005.11.001

[3] Plasticity of cortical projections after stroke [J].

Carmichael, ST .

NEUROSCIENTIST, 2003, 9 (01) :64-75

[4] Cerebral Microbleeds and Recurrent Stroke Risk Systematic Review and Meta-Analysis of Prospective Ischemic Stroke and Transient Ischemic Attack Cohorts [J].

Charidimou, Andreas ;

Kakar, Puneet ;

Fox, Zoe ;

Werring, David J. .

STROKE, 2013, 44 (04) :995-+

[5] Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke [J].

Chen, Zu-Lin ;

Yao, Yao ;

Norris, Erin H. ;

Kruyer, Anna ;

Jno-Charles, Odella ;

Akhmerov, Akbarshakh ;

Strickland, Sidney .

JOURNAL OF CELL BIOLOGY, 2013, 202 (02) :381-395

[6] Silent Infarcts and Cerebral Microbleeds Modify the Associations of White Matter Lesions With Gait and Postural Stability Population-Based Study [J].

Choi, Philip ;

Ren, Mandy ;

Phan, Thanh G. ;

Callisaya, Michele ;

Ly, John V. ;

Beare, Richard ;

Chong, Winston ;

Srikanth, Velandai .

STROKE, 2012, 43 (06) :1505-+

[7] Cerebral Small Vessel Disease and Risk of Death, Ischemic Stroke, and Cardiac Complications in Patients With Atherosclerotic Disease The Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) Study [J].

Conijn, Mandy M. A. ;

Kloppenborg, Raoul P. ;

Algra, Ale ;

Mali, Willem P. Th. M. ;

Kappelle, L. Jaap ;

Vincken, Koen L. ;

van der Graaf, Yolanda ;

Geerlings, Mirjam I. .

STROKE, 2011, 42 (11) :3105-U290

[8] Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis [J].

Dannenberg, Steffen ;

Scheitz, Jan F. ;

Rozanski, Michal ;

Erdur, Hebun ;

Brunecker, Peter ;

Werring, David J. ;

Fiebach, Jochen B. ;

Nolte, Christian H. .

STROKE, 2014, 45 (10) :2900-2905

[9]

DATTA A, 2014, PLOS ONE, V0009

[10]

de Groot JC, 2000, STROKE, V47, P145

← 1 2 3 4 5 6 7 →