Association Between Blood PLT and RBC Related Indices and Disease Activity in Patients with Rheumatoid Arthritis

被引：17

作者：

Xue, Li ^{[1
]}

Tao, Li ^{[1
]}

Sun, Haifeng ^{[2
]}

Wang, Yan ^{[1
]}

Zhang, Yanping ^{[1
]}

Lei, Na ^{[1
]}

Liu, Zeshi ^{[1
]}

Zhang, Hua ^{[1
]}

Jin, Li ^{[1
]}

Zhang, Ting ^{[1
]}

Zhang, Jing ^{[1
]}

Meng, Hao ^{[1
]}

Huang, Fang ^{[1
]}

Geng, Yan ^{[1
]}

Li, Ming ^{[3
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Clin Lab, Affiliated Hosp 2, Xian 710004, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Med Oncol 3, Shaanxi Prov Canc Hosp, Med Coll, Xian 710061, Peoples R China

[3] Xi An Jiao Tong Univ, Dept Cardiovasc Surg, Affiliated Hosp 1, Xian 710061, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2022年 / 15卷

基金：

中国国家自然科学基金;

关键词：

rheumatoid arthritis; platelets; red blood cells; hemoglobin; PLATELET; ERYTHROCYTES; SUPPRESSION; INHIBITION; CRITERIA; CELLS;

D O I：

10.2147/IJGM.S351505

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Platelet (PLT) and red blood cell (RBC) have been demonstrated to play a critical role in inflammatory processes. This study aimed to evaluate the association of blood PLT and RBC related parameters with the disease activity in rheumatoid arthritis (RA) patients, and also to investigate the role of these indices in differentiating among RA patients with different disease activity. Methods: Clinical data from RA patients were retrospectively analyzed. RA patients were divided into inactive group and active group according to DAS28-CRP. The relationship between blood PLT and RBC counts-related indices and DAS28-CRP was detected by Spearman correlation. ROC curve was used to assess the diagnostic value of these indices in differentiating active RA from inactive RA. Results: Active RA patients exhibited higher level of PLT counts but significantly lower levels of RBC counts, hemoglobin (Hb), red blood cells-platelet ratio (RPR) and hemoglobin-platelet ratio (HPR) compared with inactive RA. PLT counts were positively but RBC counts, Hb, RPR and HPR were negatively related with DAS28-CRP. Conclusion: Blood PLT and RBC related indices were significantly associated with RA disease activity. These indices may be used to distinguish active RA from inactive RA.

引用

页码：573 / 581

页数：9

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