Influenza A viruses: new research developments

被引：483
|
作者：
Medina, Rafael A. [1 ,2 ]
Garcia-Sastre, Adolfo [1 ,2 ,3 ]
机构：
[1] Mt Sinai Sch Med, Dept Microbiol & Global Hlth, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Emerging Pathogens Inst, New York, NY USA
[3] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 08期
关键词：
PATHOGENIC AVIAN INFLUENZA; SWINE-ORIGIN; 2009; LOWER RESPIRATORY-TRACT; SIALIC-ACID RECEPTORS; PANDEMIC INFLUENZA; H5N1; VIRUS; NS1; PROTEIN; H1N1; SEASONAL INFLUENZA; HUMAN HOST;
D O I：
10.1038/nrmicro2613
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Influenza A viruses are zoonotic pathogens that continuously circulate and change in several animal hosts, including birds, pigs, horses and humans. The emergence of novel virus strains that are capable of causing human epidemics or pandemics is a serious possibility. Here, we discuss the value of surveillance and characterization of naturally occurring influenza viruses, and review the impact that new developments in the laboratory have had on our understanding of the host tropism and virulence of viruses. We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years.
引用
收藏
页码：590 / 603
页数：14
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