CO2/water/surfactant ternary systems and liposome formation using supercritical CO2: A review

被引:39
作者
Lesoin, L. [1 ]
Boutin, O. [1 ]
Crampon, C. [1 ]
Badens, E. [1 ]
机构
[1] Univ Paul Cezanne Aix Marseille, Lab Modelisat Mecan & Proc Propres, UMR 6181, CNRS, F-13545 Aix En Provence 4, France
关键词
Phase behavior; Supercritical carbon dioxide; Liposome; Emulsion; Micelle; Bilayered phospholipid fragment (BPF); REVERSE-PHASE EVAPORATION; CARBON DIOXIDE MICROEMULSIONS; CANCER GENE-THERAPY; PHYSICOCHEMICAL PROPERTIES; HYDROCARBON SURFACTANTS; CO2-IN-WATER EMULSIONS; INTERFACIAL PHENOMENA; COMPUTED-TOMOGRAPHY; CATIONIC LIPOSOMES; PROCESS PARAMETERS;
D O I
10.1016/j.colsurfa.2011.01.027
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The aim of this review is to explain the various phenomena involved in liposome formation using dense gas processes and especially supercritical CO2. Before liposome formation, the review focuses on the phase behavior of CO2/water/surfactant ternary systems. First of all, the two main cases of CO2/water/surfactant fluid phase behavior are studied: reverse micelle systems and Winsor systems. Then, the various mechanisms of emulsion destabilization as a function of formulation variables (pressure, temperature and water content) are tackled. Influence of formulation variables is also addressed in the case of liposome formation during depressurization and CO2 release for dense gas techniques. Techniques using supercritical or subcritical conditions are classified according to the hydration way: in the first case, hydration is carried out under pressure and in the second one, hydration is achieved after depressurization. Hydration under pressure involves the formation of a CO2/water/surfactant system which is not the case when hydration is carried out during depressurization. An emergent tendency in liposome formation may be noted: (i) large unilamellar vesicles would appear when hydration is achieved under pressure, i.e. when liposomes are the result of two phase inversions (inversion phase from water-in-CO2 emulsion to CO2-in-water emulsion and inversion phase from CO2-in-water emulsion to liposomes); (ii) multilamellar vesicles would be formed when hydration is realized during depressurization, i.e. when liposomes are the result of one phase inversion (inversion phase from CO2-in-water to liposomes). Lastly, a model of liposome formation is developed. (C) 2011 Elsevier B.V. All rights reserved.
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页码:1 / 14
页数:14
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