Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors

被引：28

作者：

Ly, Kiev S.

Letavic, Michael A. ^{[1
]}

Keith, John M. ^{[1
]}

Miller, Jennifer M. ^{[1
]}

Stocking, Emily M. ^{[1
]}

Barbier, Ann J. ^{[1
]}

Bonaventure, Pascal ^{[1
]}

Lord, Brian ^{[1
]}

Jiang, Xiaohui ^{[1
]}

Boggs, Jamin D. ^{[1
]}

Dvorak, Lisa ^{[1
]}

Miller, Kirsten L. ^{[1
]}

Nepomuceno, Diane ^{[1
]}

Wilson, Sandy J. ^{[1
]}

Carruthers, Nicholas I. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期

关键词：

histamine H3 antagonist; serotonin reuptake inhibitor; histamine; serotonin;

D O I：

10.1016/j.bmcl.2007.11.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H-3 ligands and serotonin reuptake inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：39 / 48

页数：10

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