Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family

被引：25
|
作者：
Sconocchia, Tommaso [1 ]
Sconocchia, Giuseppe [2 ]
机构：
[1] Med Univ Graz, Div Hematol, Graz, Austria
[2] Natl Res Council CNR, Inst Translat Pharmacol, Rome, Italy
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
BMP; cancer; inflammation; immune regulation; autoimmunity; dendritic cells; T cells; macrophages; T-CELL; EXPRESSION; INHIBITION; ACTIVATION; THYMUS;
D O I：
10.3389/fimmu.2021.802346
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bone morphogenetic proteins (BMPs) are potent signaling molecules initially described as osteopromoting proteins. BMPs represent one of the members of the larger TGF beta family and today are recognized for their important role in numerous processes. Among the wide array of functions recently attributed to them, BMPs were also described to be involved in the regulation of components of the innate and adaptive immune response. This review focuses on the signaling pathway of BMPs and highlights the effects of BMP signaling on the differentiation, activation, and function of the main cell types of the immune system.
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页数：8
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