Assembly mechanism of the contractile ring for cytokinesis by fission yeast

被引：283
作者：
Vavylonis, Dimitrios [1 ,2 ,3 ]
Wu, Jian-Qiu [1 ]
Hao, Steven [4 ]
O'Shaughnessy, Ben [2 ]
Pollard, Thomas D. [1 ,4 ,5 ]
机构：
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[2] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA
[3] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA
[4] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
[5] Yale Univ, Dept Cell Biol, New Haven, CT 06520 USA
来源：
SCIENCE | 2008年 / 319卷 / 5859期
关键词：
D O I：
10.1126/science.1151086
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Animals and fungi assemble a contractile ring of actin filaments and the motor protein myosin to separate into individual daughter cells during cytokinesis. We used fluorescence microscopy of live fission yeast cells to observe that membrane- bound nodes containing myosin were broadly distributed around the cell equator and assembled into a contractile ring through stochastic motions, after a meshwork of dynamic actin filaments appeared. Analysis of node motions and numerical simulations supported a mechanism whereby transient connections are established when myosins in one node capture and exert force on actin filaments growing from other nodes.
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页码：97 / 100
页数：4
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