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Leiden Univ, Med Ctr, Dept Mol Cell Biol, Electron Microscopy Sect, Postal Zone S1-P,Room R90-021,POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Mol Cell Biol, Electron Microscopy Sect, Postal Zone S1-P,Room R90-021,POB 9600, NL-2300 RC Leiden, Netherlands