Stochastic dynamics and the evolution of mutations in stem cells

被引：16
作者：
Dingli, David [1 ,2 ]
Pacheco, Jorge M. [3 ,4 ]
机构：
[1] Mayo Clin, Coll Med, Div Hematol, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Mol Med, Rochester, MN 55905 USA
[3] Univ Minho, Dept Matemat & Aplicacoes, P-4710057 Braga, Portugal
[4] Ctr Matemat & Aplicacoes Fundamentais, ATP Grp, P-1649003 Lisbon, Portugal
来源：
BMC BIOLOGY | 2011年 / 9卷
关键词：
PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; NATURAL-HISTORY; CYCLIC NEUTROPENIA; NORMAL INDIVIDUALS; SOMATIC MUTATIONS; CD34(+) CELLS; CANCER; HEMATOPOIESIS;
D O I：
10.1186/1741-7007-9-41
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking into consideration the impact of such mutations on the reproductive fitness of cells. We show how stochastic effects can explain clinical observations, including extinction of acquired clonal stem cell disorders.
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页数：7
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