Crystal structure and DNA binding studies of a cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid

被引：10

作者：

Lin, Hai Bin ^{[1
]}

Wang, Qing Xiang ^{[1
]}

Zhang, Cong Min ^{[2
]}

Li, Wen Qi ^{[1
]}

机构：

[1] Zhangzhou Normal Univ, Dept Chem & Environm Sci, Zhangzhou 363000, Peoples R China

[2] Zhangzhou Normal Univ, Dept Biosci Tech, Zhangzhou 363000, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2011年 / 22卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Cobalt complex; DNA binding; Electronic absorption spectra; Electrochemistry;

D O I：

10.1016/j.cclet.2011.03.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline (phen) and glycollic acid (GA), [Co(GA)(2)(phen)] was synthesized and its structure was characterized by X-ray diffraction. The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods. Electronic absorption spectrum experiments showed that after interaction with DNA, the characteristic absorption peaks of [Co(GA)(2)(phen)] underwent hypochromic effect as well as red-shift. Also, the binding strength of 3.8 x 10(4) L/mol was estimated by titration method. Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA. All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode. (C) 2011 Wen Qi Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：969 / 972

页数：4

共 12 条

[1] Dipyridophenazine complexes of cobalt(III) and nickel(II): DNA-Binding and photocleavage studies [J].

Arounaguiri, S ;

Maiya, BG .

INORGANIC CHEMISTRY, 1996, 35 (14) :4267-+

[2] VOLTAMMETRIC STUDIES OF THE INTERACTION OF METAL-CHELATES WITH DNA .2. TRIS-CHELATED COMPLEXES OF COBALT(III) AND IRON(II) WITH 1,10-PHENANTHROLINE AND 2,2'-BIPYRIDINE [J].

CARTER, MT ;

RODRIGUEZ, M ;

BARD, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (24) :8901-8911

[3] OS(PHEN)(2)(DPPZ)(2+) - A RED-EMITTING DNA-PROBE [J].

HOLMLIN, RE ;

BARTON, JK .

INORGANIC CHEMISTRY, 1995, 34 (01) :7-8

[4] Cobalt complexes of terpyridine ligand: Crystal structure and photocleavage of DNA [J].

Indumathy, Ramasamy ;

Radhika, Srinivasan ;

Kanthimathi, Mookandi ;

Weyhermuller, T. ;

Nair, Balachandran Unni .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (03) :434-443

[5]

Jiao K, 2005, CHINESE CHEM LETT, V16, P517

[6] DNA binding of iron(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline [J].

Mudasir ;

Yoshioka, N ;

Inoue, H .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 77 (3-4) :239-247

[7] MIXED-LIGAND COMPLEXES OF RUTHENIUM(II) - FACTORS GOVERNING BINDING TO DNA [J].

PYLE, AM ;

REHMANN, JP ;

MESHOYRER, R ;

KUMAR, CV ;

TURRO, NJ ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (08) :3051-3058

[8] DNA binding and DNA cleavage studies of a water soluble cobalt(II) complex containing dinitrogen Schiff base ligand: The effect of metal on the mode of binding [J].

Shahabadi, Nahid ;

Kashanian, Soheila ;

Darabi, Farivash .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :4239-4245

[9]

Sheldrick G. M., 1996, PROGRAM EMPIRICAL AB

[10]

SHELDRICK M, 1997, SHELXTL V5 1 SOFTWAR

← 1 2 →