Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice

被引：16

作者：

Barbalho, Sandra M. ^{[1
]}

Damasceno, Debora C. ^{[2
]}

Machado Spada, Ana Paula ^{[3
,4
]}

Palhares, Mireia ^{[5
]}

Martuchi, Karla Aparecida ^{[6
]}

Oshiiwa, Marie ^{[7
]}

Sazaki, Viviane ^{[5
]}

da Silva, Vanessa Sellis ^{[5
]}

机构：

[1] Fac Technol & Foods Marilia, Med Sch Med Marilia UNIMAR, BR-17525902 Marilia, SP, Brazil

[2] UNESP, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP, Brazil

[3] Univ Sao Paulo, Dept Biochem, Fac UNINOVE, BR-01041000 Sao Paulo, Brazil

[4] Univ Sao Paulo, SENAC, BR-01041000 Sao Paulo, Brazil

[5] Univ Metodista Piracicaba, Dept Nutr, UNIMEP, BR-16400680 Lins, SP, Brazil

[6] Frigorificos Bertin SA, Dept Nutr, BR-16400000 Lins, SP, Brazil

[7] FATEC, Fac Technol & Foods Marilia, BR-17506000 Marilia, SP, Brazil

来源：

EXPERIMENTAL DIABETES RESEARCH | 2011年

关键词：

DC; FRUIT; POLYPHENOL EXTRACT; METABOLIC SYNDROME; AQUEOUS EXTRACT; OVERWEIGHT; MECHANISM; PREGNANCY; LEAVES; ADULTS;

D O I：

10.1155/2011/173647

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.

引用

页数：6

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