Progress and developments in the turbo Grignard reagent i-PrMgCl•LiCl: a ten-year journey

被引：137

作者：

Bao, Robert Li-Yuan ^{[1
]}

Zhao, Rong ^{[1
]}

Shi, Lei ^{[1
]}

机构：

[1] Harbin Inst Technol, Acad Fundamental & Interdisciplinary Sci, Inst Organ Chem, Harbin 150080, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 32期

关键词：

CROSS-COUPLING REACTIONS; BROMINE-MAGNESIUM EXCHANGE; DIELS-ALDER REACTIONS; POLYFUNCTIONAL ARYL; REGIOSELECTIVE FUNCTIONALIZATION; STEREOSELECTIVE PREPARATION; ALKENYLMAGNESIUM REAGENTS; PARA-DIFUNCTIONALIZATION; PHOSPHOROTHIOATE ESTERS; FULL FUNCTIONALIZATION;

D O I：

10.1039/c4cc10194d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over the past decade, the effectiveness of i-PrMgCl center dot LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl center dot LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl center dot LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.

引用

页码：6884 / 6900

页数：17

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