Progress and developments in the turbo Grignard reagent i-PrMgCl•LiCl: a ten-year journey

被引：132
作者：
Bao, Robert Li-Yuan [1 ]
Zhao, Rong [1 ]
Shi, Lei [1 ]
机构：
[1] Harbin Inst Technol, Acad Fundamental & Interdisciplinary Sci, Inst Organ Chem, Harbin 150080, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 32期
关键词：
CROSS-COUPLING REACTIONS; BROMINE-MAGNESIUM EXCHANGE; DIELS-ALDER REACTIONS; POLYFUNCTIONAL ARYL; REGIOSELECTIVE FUNCTIONALIZATION; STEREOSELECTIVE PREPARATION; ALKENYLMAGNESIUM REAGENTS; PARA-DIFUNCTIONALIZATION; PHOSPHOROTHIOATE ESTERS; FULL FUNCTIONALIZATION;
D O I：
10.1039/c4cc10194d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Over the past decade, the effectiveness of i-PrMgCl center dot LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl center dot LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl center dot LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.
引用
收藏
页码：6884 / 6900
页数：17
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