The complement system

被引：631

作者：

Sarma, J. Vidya ^{[1
]}

Ward, Peter A. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CELL AND TISSUE RESEARCH | 2011年 / 343卷 / 01期

关键词：

Complement; Activation pathways; Anaphylatoxins; BINDING-LECTIN; IMMUNE-RESPONSE; INNATE IMMUNITY; FRAGMENTS C5A; RECEPTOR; ACTIVATION; C5L2; DEFICIENCY; EXPRESSION; EVASION;

D O I：

10.1007/s00441-010-1034-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complement deficiencies are the underlying cause of the pathophysiology of many diseases such as systemic lupus erythematosus and asthma. This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses.

引用

页码：227 / 235

页数：9

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