Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells

被引：14
作者：
Xu, Yizhou [1 ,2 ,3 ,4 ]
Zhang, Chu [1 ,2 ]
Wang, Ningfu [1 ,2 ]
Ling, Feng [1 ,2 ]
Li, Peizhang [1 ,2 ]
Gao, Yan [1 ,2 ]
Hua, Wei [3 ,4 ]
机构：
[1] Nanjing Med Univ, Dept Cardiol, Hangzhou Peoples Hosp 1, Hangzhou 310006, Zhejiang, Peoples R China
[2] Nanjing Med Univ, Hangzhou Hosp, Hangzhou 310006, Zhejiang, Peoples R China
[3] Chinese Acad Med Sci, Fu Wai Hosp, Cardiac Arrhythmia Ctr, Cardiovasc Inst, Beijing 100037, Peoples R China
[4] Peking Union Med Coll, Beijing 100037, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 404卷 / 04期
关键词：
Adiponectin; AdipoR1; LTBR; Yeast two-hybrid screen; NF-kappa B; GLOBULAR ADIPONECTIN; CARDIOVASCULAR-DISEASE; TRANSCRIPTION FACTOR; DEFICIENT MICE; ATHEROSCLEROSIS; PROLIFERATION; ACTIVATION; EXPRESSION;
D O I：
10.1016/j.bbrc.2010.12.110
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown. In this study, we identified the lymphotoxin (LT)-beta receptor (LTBR) as an interacting partner of human AdipoR1 by using a yeast two-hybrid screening. The interaction between LTBR and AdipoR1 was confirmed by co-immunoprecipitation and co-localization analysis. Furthermore, adiponectin incubation inhibited lymphotoxin-induced NF-kappa B activation and the expression of adhesion molecules in human umbilical vein endothelial cells. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappa B pathway. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：1060 / 1064
页数：5
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