Long Intergenic Noncoding RNAs: New Links in Cancer Progression

被引：591

作者：

Tsai, Miao-Chih

Spitale, Robert C.

Chang, Howard Y.

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA

来源：

CANCER RESEARCH | 2011年 / 71卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; MICRORNA; METASTASIS; PROTEINS; IDENTIFICATION; TRANSLATION; ANTAGOMIRS; INHIBITORS; COMPLEXES; SCAFFOLD;

D O I：

10.1158/0008-5472.CAN-10-2483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets. Cancer Res; 71(1); 3-7. (C) 2011 AACR.

引用

页码：3 / 7

页数：5

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