Dielectric Coagulometry: A New Approach To Estimate Venous Thrombosis Risk

被引：36

作者：

Hayashi, Yoshihito ^{[1
]}

Katsumoto, Yoichi ^{[1
]}

Omori, Shinji ^{[1
]}

Yasuda, Akio ^{[1
]}

Asami, Koji ^{[2
]}

Kaibara, Makoto ^{[3
]}

Uchimura, Isao ^{[4
]}

机构：

[1] Sony Corp, Life Sci Lab, Adv Mat Labs, Tokyo 1138510, Japan

[2] Kyoto Univ, Lab Mol Aggregat Anal, Div Multidisciplinary Chem, Inst Chem Res, Kyoto 6110011, Japan

[3] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[4] Tokyo Med & Dent Univ, Dept Endocrinol & Metab, Tokyo 1138510, Japan

来源：

ANALYTICAL CHEMISTRY | 2010年 / 82卷 / 23期

关键词：

TISSUE FACTOR; FACTOR-IX; BLOOD; AGGREGATION; MEMBRANE; PLASMA;

D O I：

10.1021/ac101927n

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We present dielectric coagulometry as a new technique to estimate the risk of venous thrombosis by measuring the permittivity change associated with the blood coagulation process The method was first tested for a simple system of animal erythrocytes suspended in fibrinogen, solution, where the coagulation rate was controlled by changing the amount of thrombin added to the suspension Second, the method was applied to a more realistic system of human whole blood, and the inherent coagulation process was monitored without artificial acceleration by a coagulation initiator The time dependence of the permittivity at a frequency around 1 M Hz showed a distinct peak at a time that corresponds to the clotting time Our theoretical modeling revealed that the evolution of heterogeneity and the sedimentation in the system cause the peak of the permittivity

引用

页码：9769 / 9774

页数：6

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