Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes in Oropharyngeal Cancer Stratified by Human Papillomavirus Status

被引：142

作者：

Huang, Shao Hui ^{[1
]}

Waldron, John N. ^{[1
,2
]}

Milosevic, Michael ^{[1
]}

Shen, Xiaowei ^{[3
]}

Ringash, Jolie ^{[1
]}

Su, Jie ^{[3
]}

Tong, Li ^{[1
]}

Perez-Ordonez, Bayardo ^{[4
]}

Weinreb, Ilan ^{[4
]}

Bayley, Andrew J. ^{[1
]}

Kim, John ^{[1
]}

Hope, Andrew ^{[1
]}

Cho, B. C. John ^{[1
]}

Giuliani, Meredith ^{[1
]}

Razak, Albiruni ^{[5
]}

Goldstein, David ^{[2
]}

Shi, Willa ^{[6
]}

Liu, Fei-Fei ^{[1
,6
]}

Xu, Wei ^{[3
]}

O'Sullivan, Brian ^{[1
,2
,6
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON M5G 2M9, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Dept Pathol, Toronto, ON M5G 2M9, Canada

[5] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol, Toronto, ON M5G 2M9, Canada

[6] Univ Hlth Network, Ontario Canc Inst, Toronto, ON, Canada

来源：

CANCER | 2015年 / 121卷 / 04期

关键词：

human papillomavirus (HPV); lymphocytes; monocytes; neutrophils; oropharyngeal cancer; outcomes; INFILTRATING LYMPHOCYTES; TUMOR ANGIOGENESIS; POOR-PROGNOSIS; HEAD; HPV; CHEMORADIOTHERAPY; RADIOTHERAPY; CELLS; GRANULOCYTES; CHEMOTHERAPY;

D O I：

10.1002/cncr.29100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUNDThe objective of this study was to investigate the prognostic value of the pretreatment circulating neutrophil count (CNC), circulating monocyte count (CMC), and circulating lymphocyte count (CLC) in human papillomavirus (HPV)-related (HPV+) and HPV-unrelated (HPV-) oropharyngeal cancer (OPC). METHODSAll p16-confirmed HPV+ and HPV- OPC cases treated with chemoradiotherapy from 2000 to 2010 were included. Overall survival (OS) and recurrence-free survival (RFS) were compared for high and low CNCs, CMCs, and CLCs (dichotomized by median values). A multivariate analysis (MVA) confirmed their prognostic value in HPV+ and HPV- tumors, respectively. RESULTSFive hundred ten HPV+ OPC cases and 192 HPV- OPC cases were included. The HPV+ cohort had lower CNC and CMC values but a CLC similar to that of the HPV- patients (P<.01). The median follow-up was 4.8 years. In the HPV+ cohort, a high CNC or CMC correlated with reduced OS and RFS in comparison with a low CNC or CMC (P<.01 for all), but no difference was evident in OS (P=.30) or RFS (P=.10) with the CLC. MVA confirmed that a higher CNC or CMC independently predicted lower OS (hazard ratio [HR] for CNC, 1.14, P<.01; HR for CMC, 2.95, P<.01) and lower RFS (HR for CNC, 1.11, P<.01; HR for CMC, 3.39, P<.01), whereas a higher CLC was associated with higher RFS (HR, 0.66, P=.03) and marginally higher OS (HR, 0.80, P=.08). In the HPV- cohort, CNC, CMC, and CLC were not predictive of OS (P=.16, P=.86, and P=.14) or RFS (P=.61, P=.59, and P=.62). CONCLUSIONSThis relatively large cohort study demonstrates that a high CNC and a high CMC independently predict inferior OS and RFS, whereas a high CLC predicts better RFS and marginally better OS in HPV+ OPC patients. This association was not apparent in HPV- patients. Cancer 2015;121:545-555. (c) 2014 American Cancer Society. This relatively large cohort study reports an intriguing hypothesis-generating observation: high pretreatment neutrophil counts, high pretreatment monocyte counts, and low pretreatment lymphocyte counts independently predict inferior survival and disease control for human papillomavirus-positive oropharyngeal cancer patients, whereas a predictive value for human papillomavirus-negative patients is not apparent.

引用

页码：545 / 555

页数：11

共 51 条

[1] Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment [J].

Ahn, G-One ;

Tseng, Diane ;

Liao, Cho-Hwa ;

Dorie, Mary Jo ;

Czechowicz, Agnieszka ;

Brown, J. Martin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8363-8368

[2] Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy Experimental models and clinical perspectives [J].

Ahn, G-One ;

Brown, J. Martin .

CELL CYCLE, 2009, 8 (07) :970-976

[3] Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma [J].

An, Xin ;

Ding, Pei-Rong ;

Wang, Feng-Hua ;

Jiang, Wen-Qi ;

Li, Yu-Hong .

TUMOR BIOLOGY, 2011, 32 (02) :317-324

[4] The interplay between HPV and host immunity in head and neck squamous cell carcinoma [J].

Andersen, Anne Skou ;

Solling, Anne Sophie Koldjaer ;

Ovesen, Therese ;

Rusan, Maria .

INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (12) :2755-2763

[5]

[Anonymous], PHARYNX

[6]

[Anonymous], J CLIN ONCO IN PRESS

[7]

[Anonymous], HEAD NECK IN PRESS

[8]

[Anonymous], HEAD NECK IN PRESS

[9]

[Anonymous], WHITE BLOOD CELLS WB

[10] Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer [J].

Balermpas, P. ;

Michel, Y. ;

Wagenblast, J. ;

Seitz, O. ;

Weiss, C. ;

Roedel, F. ;

Roedel, C. ;

Fokas, E. .

BRITISH JOURNAL OF CANCER, 2014, 110 (02) :501-509

← 1 2 3 4 5 6 →