Optimal Control of an Inflammatory Immune Response Model

被引：0

作者：

Bara, Ouassim ^{[1
]}

Day, Judy ^{[2
]}

Djouadi, Seddik M. ^{[1
]}

机构：

[1] Univ Tennessee, Dept Elect Engn & Comp Sci, Knoxville, TN 37996 USA

[2] Univ Tennessee, Dept Math, Knoxville, TN 37996 USA

来源：

2015 54TH IEEE CONFERENCE ON DECISION AND CONTROL (CDC) | 2015年

关键词：

Optimal control; Immunology model; Ordinary differential equation system; STABILIZATION;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A reduced model of an acute inflammatory response to severe infection is considered. Regulation of the inflammatory response is crucial for restoring the patient to a healthy state. Therefore, an optimal control strategy given by a pro-inflammatory and anti-inflammatory drug treatment are derived. A study of controllability is also presented and the existence result is established. The optimality system composed of four differential equation and their corresponding adjoint equations are solved numerically. Simulation results are presented and different drug treatment strategies are discussed.

引用

页码：1283 / 1288

页数：6

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