NLRP3 Inflammasome and Inflammatory Diseases

被引：284
作者：
Wang, Zheng [1 ]
Zhang, Simei [1 ]
Xiao, Ying [1 ]
Zhang, Wunai [1 ]
Wu, Shuai [1 ]
Qin, Tao [1 ]
Yue, Yangyang [1 ]
Qian, Weikun [1 ]
Li, Li [2 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Ophthalmol, Xian 710061, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷
基金：
中国国家自然科学基金;
关键词：
NF-KAPPA-B; IL-1-BETA PRODUCTION; NALP3; INFLAMMASOME; BAY; 11-7082; ALZHEIMERS-DISEASE; EPITHELIAL-CELLS; ACTIVATION; MECHANISMS; INHIBITOR; RECEPTOR;
D O I：
10.1155/2020/4063562
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.
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页数：11
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