NLRP3 Inflammasome and Inflammatory Diseases

被引：262

作者：

Wang, Zheng ^{[1
]}

Zhang, Simei ^{[1
]}

Xiao, Ying ^{[1
]}

Zhang, Wunai ^{[1
]}

Wu, Shuai ^{[1
]}

Qin, Tao ^{[1
]}

Yue, Yangyang ^{[1
]}

Qian, Weikun ^{[1
]}

Li, Li ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Ophthalmol, Xian 710061, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷

基金：

中国国家自然科学基金;

关键词：

NF-KAPPA-B; IL-1-BETA PRODUCTION; NALP3; INFLAMMASOME; BAY; 11-7082; ALZHEIMERS-DISEASE; EPITHELIAL-CELLS; ACTIVATION; MECHANISMS; INHIBITOR; RECEPTOR;

D O I：

10.1155/2020/4063562

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.

引用

页数：11

共 50 条

[21] The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases
Ding, Yong
Fu, Xiaodi
Wang, Qimeng
Liu, Huiyang
Wang, Honggang
Wu, Dongdong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)
[22] Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases
Guan, Yadi
Han, Fang
FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2020, 14
[23] NLRP3 Inflammasome in Metabolic-Associated Kidney Diseases: An Update
Xiong, Wei
Meng, Xian-Fang
Zhang, Chun
FRONTIERS IN IMMUNOLOGY, 2021, 12
[24] Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
Seok, Jin Kyung
Kang, Han Chang
Cho, Yong-Yeon
Lee, Hye Suk
Lee, Joo Young
ARCHIVES OF PHARMACAL RESEARCH, 2021, 44 (01) : 16 - 35
[25] Role of the NLRP3 inflammasome in autoimmune diseases
Li, Zhe
Guo, Jialong
Bi, Liqi
BIOMEDICINE & PHARMACOTHERAPY, 2020, 130
[26] Targeting the NLRP3 Inflammasome in Glaucoma
Coyle, Sophie
Khan, Mohammed Naeem
Chemaly, Melody
Callaghan, Breedge
Doyle, Chelsey
Willoughby, Colin E.
Atkinson, Sarah D.
Gregory-Ksander, Meredith
McGilligan, Victoria
BIOMOLECULES, 2021, 11 (08)
[27] Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases
Ozenver, Nadire
Efferth, Thomas
PHARMACOLOGICAL RESEARCH, 2021, 170
[28] Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors
Lou, Shengying
Wu, Miaolian
Cui, Sunliang
CURRENT MEDICINAL CHEMISTRY, 2024, 31 (15) : 2021 - 2051
[29] The role of the NLRP3 inflammasome in pulmonary diseases
Hosseinian, Nima
Cho, Young
Lockey, Richard F.
Kolliputi, Narasaiah
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2015, 9 (04) : 188 - 197
[30] NLRP3 inflammasome in cardiovascular diseases: an update
Mo, Binhai
Ding, Yudi
Ji, Qingwei
FRONTIERS IN IMMUNOLOGY, 2025, 16

← 1 2 3 4 5 →